每周二、四为您推送近期幽门螺杆菌相关文献摘要，追踪学术进展。
EffectofHelicobacterpyloriongastrointestinalmicrobiota:apopulation-basedstudyinLinqu,ahigh-riskareaofgastriccancer
幽门螺杆菌对胃肠道菌群的影响：胃癌高风险地区临朐县的人群研究
Abstract摘要
Objective:
GastrointestinalmicrobiotamaybeinvolvedinHelicobacterpylori-associatedgastriccancerdevelopment.TheaimofthisstudywastoexplorethepossiblemicrobialmechanismsingastriccarcinogenesisandpotentialdysbiosisarisingfromH.pyloriinfection.
目的：
胃肠道菌群可能参与了幽门螺杆菌相关的胃癌发展。本研究的目的是探讨微生物在由幽门螺杆菌感染引起的胃癌和潜在菌群失调中的可能机理和作用。
Design:
Deepsequencingofthemicrobial16SribosomalRNAgenewasusedtoinvestigatealterationsinpairedgastricbiopsiesandstoolsamplesin58subjectswithsuccessfuland57subjectswithfailedanti-H.pyloritreatment,relativeto49H.pylorinegativesubjects.
设计：
微生物16SrRNA基因的深度测序被用于研究58例根除Hp成功者和57例根除Hp失败患者胃活检和粪便样本的变化，并且同49例幽门螺杆菌阴性受试者进行对比。
Results:
InH.pyloripositivesubjects,richnessandShannonindexesincreasedsignificantly(bothp0.)aftersuccessfuleradicationandshowednodifferencetothoseofnegativesubjects(p=0.forrichnessandp=0.forShannonindex).Differentialtaxaanalysisidentified18significantlyalteredgastricgeneraaftereradication.The
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